The chemotherapy of experimental amoebiasis
digital file Colour Silent 1947 6:38
Summary: Young rats are suitable laboratory hosts for caecal infection with Entamoeba histolytica. This film shows the laboratory technique for injecting a concentrated suspension of amoebae into the caecum and the thickened and ulcerated appearance of the caecum a week later. The rats are given regular doses of drugs during the week following inoculation and the amoebicidal activity of the drugs is then assessed by determining what proportion of the rats are amoeba - free after a given dose of the drug. 1 segment.
Title number: 18115
LSA ID: LSA/21272
Description: Segment 1 The intertitles explain that the following experiments aid the search for synthetic drugs for the treatment of amoebiasis in humans. They also explain that young rats are suitable hosts for caecal infection with entamoeba histolytica. The cultivated amoebae are shown. A rat is shaved and cut open and its caecun injected with the amoebae. It is sewn back up and shown the next day. After one week it is cut open and the thickened and ulcerated caecum is shown. The infected caecum is compared with a normal caecum. An experiment is carried out in which rats are infected and then one group is left untreated and the other treated with emetine. The two sets of caeca are compared. The results from different strengths of emetine treatment are shown using graphs and charts. Time start: 00:00:00:00 Time end: 00:06:38:20 Length: 00:06:38:20
Keywords: Parasitic Sensitivity Tests; Laboratory Animal Science; Entamoeba histolytica -- drug effects; Emetine; Amebiasis; Cecum
Locations: United Kingdom; England