digital file Black & White Sound 1971 31:09
Summary: Here, W.I. Cranston, Professor of Medicine at St Thomas's Hospital Medical School, London, talks about fever. A summary accompanying the cassette reads: The programme briefly reviews early experiments on the mechanism of production of fever. Evidence is shown that bacterial pyrogens or endotoxics are not the cause of fever in disease. The distinction is made between endotoxin and leucocyte or endogenous pyrogen. Professor Cranston discusses the production of human leucocyte pyrogen, the mechanism of production, its release by cells, its sites of action in the central nervous system and the evidence for its presence in human febrile illnesses. 5 segments.
Title number: 18380
LSA ID: LSA/21537
Description: Segment 1 Gilliland introduces Cranston. Cranston briefly narrates the history of research into the understanding of fever.He shows how endotoxin was injected into patients with typhoid fever in an attempt to lower their fever. Time start: 00:00:00:00 Time end: 00:05:05:00 Length: 00:05:05:00 Segment 2 Cranston refers to a graph which compares the temperature readings of a volunteer following injection with a bacterial pyrogen, firstly in saline then after having been incubated in blood. Bacterial and leukocyte pyrogens are also compared. Time start: 00:05:05:00 Time end: 00:10:29:00 Length: 00:05:24:00 Segment 3 Cranston describes how leukocyte pyrogens are formed from white cells. Time start: 00:10:29:00 Time end: 00:15:06:00 Length: 00:04:37:00 Segment 4 A diagram is shown which reveals which areas of the brain react to infusions of leukocyte pyrogen then further diagrams explaining how leukocyte pyrogens lead to a rise in temperature. These levels are showin in a patient with malaria. Time start: 00:15:06:00 Time end: 00:21:05:10 Length: 00:05:59:10
Credits: With Professor WI Cranston, St Thomas's Hospital Medical School, University of London. Introduced by Dr Ian Gilliland. Produced by Peter Bowen.
Further information: This video is one of more than 120 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest.The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.
Locations: United Kingdom; England; London; University of London