digital file Black & White Sound 1971 31:09

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Summary: Here, W.I. Cranston, Professor of Medicine at St Thomas's Hospital Medical School, London, talks about fever. A summary accompanying the cassette reads: The programme briefly reviews early experiments on the mechanism of production of fever. Evidence is shown that bacterial pyrogens or endotoxics are not the cause of fever in disease. The distinction is made between endotoxin and leucocyte or endogenous pyrogen. Professor Cranston discusses the production of human leucocyte pyrogen, the mechanism of production, its release by cells, its sites of action in the central nervous system and the evidence for its presence in human febrile illnesses. 5 segments.