Mitochondrial biogenesis

digital file Black & White Sound 1973 27:40

From:

Summary: The following summary appears with the cassette: Mitochondria are unique subcellular organelles they contain all the cyto-plasmic DNA, make messenger RNA and synthesize protein on mitoribosomes. These proteins are essential to the formation of cytochrome oxidase. Cells which lack cytochrome oxidase (anaerobic bacteria) are killed by exposure to oxygen whereas higher organisms (eukaryotes) cannot survive in its absence. Geological evidence indicates that the primitive earth was anaerobic and that the earliest life forms were also anaerobic. There is evidence that the eukaryotes may have evolved from a symbiotic relationship between a primitive anaerobe and a primitive aerobe. Drugs which block protein synthesis on mitochondria (e.g. chloramphenicol) also block synthesis of cytochrome oxidase and can be lethal to animals. 4 segments.

Full record

Title number: 18376

LSA ID: LSA/21533

Description: Segment 1 Gilliland introduces Work. Work describes how the mitochondria of the body work to produce energy. A slide is shown to illustrate how, when a cell divides, mitochondria can be seen at high magnification. Time start: 00:00:00:00 Time end: 00:06:56:00 Length: 00:06:56:00 Segment 2 Work shows a 3-dimensional model of a ribosome. He discusses the relationship between mitochondria and DNA copying. Time start: 00:06:56:00 Time end: 00:12:18:00 Length: 00:05:22:00 Segment 3 Work shows diagrams depicting the oldest known organic deposits and earliest organisms of the earth. He refers to tables which list the early compounds necessary for the creation of life and discusses the importance of photosynthesis. Time start: 00:12:18:00 Time end: 00:21:10:00 Length: 00:08:52:00 Segment 4 Work talks about antibiotics, giving details about how their effects work on different protein syntheses. He shows electron micrographs of mitochondrial mutation. Work ends the lecture by noting that with the 50,000 unexplored genes in the nucleus of mitochondria, they hold many surprises for researchers in the future. Time start: 00:21:10:00 Time end: 00:27:40:03 Length: 00:06:30:03

Credits: Presented by Dr Thomas S Work. Introduced by Dr Ian Gilliland. Produced by David R Clark.

Further information: This video is one of more than 120 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.

Keywords: Mitochondria; Biogenesis

Locations: United Kingdom; England; London; University of London

From:

Wellcome Collection

Locations: University of London

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Mitochondrial biogenesis

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