Description: Segment 1 Lachmann starts the lecture by describing, briefly, what autoallergy is - an allergic response to components of a creature's own tissues. He discusses historical perceptions of the process from the time of Ehrlich and Burnet. Lachmann states that autoallergy is not as dangerous a process as was previously believed and is perhaps more similar to other allergic processes than was previously thought. Time start: 00:00:00:00 Time end: 00:05:25:00 Length: 00:05:25:00 Segment 2 Lachmann talks about which kind of antigens cause immunological unresponsiveness, therefore produce no notable allergic responses. He explains how the genetic code of an individual plays an important role in what they will be allergic to experiments with different strains of mice are referred to to illustrate this point. Time start: 00:05:25:00 Time end: 00:09:14:11 Length: 00:03:49:11 Segment 3 Lachmann discusses blocking factors that might prevent immune or allergic responses in different individuals. He refers to experiments in which cells have been artificially rendered insensitive to specific antigens. He introduces the concept of suppressor T-cells which block the action of B-cells which are the primary cells which react to antigens. Time start: 00:09:14:11 Time end: 00:14:50:18 Length: 00:05:36:07 Segment 4 Lachmann moves on to talk more specifically about autoallergy, the mechanisms which cause a response to a creature's own antigens. He describes how autoantibody formation is actually very common and often nobody would know that the process is taking place - for instance when antibodies to spermatozoa are produced, they do not destroy the spermatozoa. Time start: 00:14:50:18 Time end: 00:20:03:00 Length: 00:05:12:07 Segment 6 Lachmann discusses specific autoimmune diseases occuring in animals - for instance, the New Zealand black mouse which suffers from haemolytic anaemia and leads to a specific kind of leukaemia. Time start: 00:25:06:00 Time end: 00:30:32:00 Length: 00:05:26:00. Segment 7 Lachmann looks in more detail at leukaemia cells, particularly the C-type leukaemia virus and analyses the genetic and immune response elements associated with the virus. In a similar way, he discusses lupus, another autoimmune disease which can also be studied in mice. Lachmann concludes by outlining the similarities and differences between autoallergic reactions and other antigens. He stresses again that not all autoallergic reactions are associated with disease. Time start: 00:30:32:00 Time end: 00:36:20:24 Length: 00:05:48:24