Atherosclerosis: families at risk
digital file Black & White Sound 1975 29:40
Summary: Two aspects of atherosclerosis are considered. First, Joan Slack reviews the relative contributions of the genetic and environmental causes, then June Lloyd talks about screening for familial hypercholesterolaemia in children and currently available treatments. 6 segments.
Title number: 18288
LSA ID: LSA/21445
Description: Segment 1 Opening titles include scenes of crowded London streets, traffic, pollution, fatty food frying, callipers measuring skin fat and a blood pressure gauge. Professor June Lloyd introduces the programme, then is shown seated at a table with Joan Slack. Slack talks about the increased risk of coronary disease in families of coronary patients she shows the statistics for this in a table comparing male and female patients. She then refers to twin studies to show the genetic background to coronary disease the results show an increased risk amongst females with a family history of coronary disease. Time start: 00:00:00:00 Time end: 00:05:06:13 Length: 00:05:06:13 Segment 2 Slack explains the theory of inheritance of total liability to a common disorder, drawing on a diagram as she goes. She explains also the concept of heritability and points out that other factors need to be considered when looking at family studies, such as environmental factors. Slack shows a chart listing environmental factors that may be passed on through family influence such as obesity and smoking. Time start: 00:05:06:13 Time end: 00:09:11:13 Length: 00:04:05:00 Segment 3 Slack talks about lipid levels as a risk factor for coronary heart disease. She shows a diagram from the National Pooling Project which shows the distribution of cholesterol levels in the American population and plots it against coronary disease those with familial hypercholesterolaemia are at much greater risk of coronary death than those without the condition. Time start: 00:09:11:13 Time end: 00:14:09:00 Length: 00:04:57:12 Segment 4 Slack and Lloyd discuss the possibility of a screening test for familial hypercholesterolaemia. Lloyd talks about the value of testing newborn infants for cholesterol levels. She feels that population screening is not an option but screening among families with a known history of coronary heart disease may prove very valuable. She shows a diagram of a family tree and gives an account of a family with a history of hypercholesterolaemia. How young should a child be when treatment starts? Lloyd suggests that cholesterol serum lowering drugs could be given from 1 year upwards but that diet must also be monitored. Time start: 00:14:09:00 Time end: 00:19:51:19 Length: 00:05:42:19 Segment 6 A short film is shown in which Lloyd sits with a young girl as she mixes her medicine into a glass of Pepsi. Lloyd, to camera, explains that this was staged as an illustration to show how difficult it can be to get young children to take medicine on a regular basis for a long period of time. Lloyd then summarises the programme with four points: that coronary heart disease runs in families, that families with coronary heart disease history should be assessed, that children in particular in these families should be focused on and that any other factors contributing to the possibility of future heart disease should also be treated. Time start: 00:25:10:15 Time end: 00:29:41:09 Length: 00:04:30:19
Credits: Presented by Professor June Lloyd and Dr Joan Slack, Institute of Child Health. Made for British Postgraduate Medical Foundation. Made by University of London Audio-Visual Centre.
Further information: This video is one of more than 120 titles, originally broadcast on Channel 7 of the ILEA closed-circuit television network, given to Wellcome Trust from the University of London Audio-Visual Centre shortly after it closed in the late 1980s. Although some of these programmes might now seem rather out-dated, they probably represent the largest and most diversified body of medical video produced in any British university at this time, and give a comprehensive and fascinating view of the state of medical and surgical research and practice in the 1970s and 1980s, thus constituting a contemporary medical-historical archive of great interest. The lectures mostly take place in a small and intimate studio setting and are often face-to-face. The lecturers use a wide variety of resources to illustrate their points, including film clips, slides, graphs, animated diagrams, charts and tables as well as 3-dimensional models and display boards with movable pieces. Some of the lecturers are telegenic while some are clearly less comfortable about being recorded all are experts in their field and show great enthusiasm to share both the latest research and the historical context of their specialist areas.
Keywords: Arteriosclerosis; Cardiology
Locations: United Kingdom; England; London; University of London