Description: Segment 1 The opening credits show city streets, pollution, cigarette smoking, frying food, the measuring of a lump of skin fat, a blood pressure gauge, cholesterol molecules and a crowd with a chunk of people obliterated from it. Dr Barry Lewis talks to camera. He introduces the subject saying that atheroscloerosis can cause myocardial infarction, angina pectoris and sudden death. He shows a chart detailing the mortalitiy statistics of heart disease in the UK which has risen over the last 40 years. He shows a graph based on studies by Ancel Keys into the relationship between diet, cholesterol and heart disease. Lewis introduces Professor Neville Woolf. Woolf shows a photograph of an atherosclerotic artery and explains how its appearance allows us to recognise atherosclerosis. He then refers to a diagram showing the progress of atherosclerosis over a lifetime. Time start: 00:00:00:00 Time end: 00:07:44:00 Length: 00:07:44:00 Segment 2 Woolf refers to a series of slides showing microscopic depictions of various atherosclerotic lesions within different arterial locations. He describes the pathology of each of them in much depth. Time start: 00:07:44:00 Time end: 00:12:25:00 Length: 00:05:19:00 Segment 3 Woolf shows a chart listing features which lead to a coronary clinical event he is keen to point out that atherosclerosis alone is not the only contributing factor involved in a serious coronary event. He introduces the subject of the atherosclerotic plaque and invites Professor Colin Adams to talk further about it. Adams describes, using charts and graphs, how arterial lipid accumulations (cholesterol) can lead to the development of plaques over time and atheroscleroma scarring. He hands back to Woolf to discuss this further. Time start: 00:12:25:00 Time end: 00:17:40:00 Length: 00:05:15:00 Segment 4 Woolf discusses the link between atherosclerotic plaques and thrombosis, he shows slides to illustrate what these look like. He refers to an experiment in which an artificial thrombus was produced on an arterial wall he shows slides detailing the results of this experiment performed on a pig's artery. Time start: 00:17:40:00 Time end: 00:22:32:00 Length: 00:04:52:00 Segment 6 Woolf talks about things known to damage the endothelium such as cigarette smoking and poor diet he describes how this happens then hands back to Lewis. Lewis shows a slide which compares the results of an experiment in rhesus monkeys with atherosclerosis, before and after a cholesterol-reducing diet. Finally, all three speakers are seen sitting around a table whilst Woolf addresses the camera and advises caution in making too strong a connection without enough evidence to the connection between arterial wall disease and cardiological clinical events. Time start: 00:30:08:00 Time end: 00:38:38:15 Length: 00:08:30:15